Transcriptional processes in a cell are fundamentally linked to the state of the epigenome, which helps facilitate gene expression or repression. In recent years, a variety of targeted epigenome editing tools based on the CRISPR-dCas9 system have been developed, allowing precise manipulation of some modifications and interrogation of their roles in gene regulation. However, these tools often display substantial context dependency, with highly variable efficacy between target genes and cell types, potentially due to underlying variation in the complement of chromatin modifications present. While simultaneous recruitment of multiple distinct ‘effector’ chromatin regulators has shown improvements in efficacy, these systems typically lack control over which effectors bind and their spatial organisation with respect to the dCas9 docking platform. To overcome these limitations and facilitate further exploration of effector combinations, we have created a new modular combinatorial epigenome editing platform, called SSSavi. This system acts as an interchangeable and reconfigurable docking platform fused to dCas9 that enables simultaneous recruitment of up to four different effectors. This customizable system allows precise control and reconfiguration of the effector composition and spatial ordering of their binding, providing enhanced flexibility over existing systems. We demonstrate the activity and specificity of the SSSavi system and compare it to existing multi-effector targeted transcriptional regulation systems, establishing the efficacy of the tool. Furthermore, by altering the spatial ordering of effector recruitment, across multiple target genes and cell lines, we demonstrate the importance of effector recruitment order for effective transcriptional regulation. Together, the SSSavi system offers the flexibility to more easily explore effector co-recruitment to specific loci, to enhance regulatory capacity and potentially alter chromatin contexts previously resistant to targeted epigenomic editing.